هكساسيكلين
التركيب :
كل ١جرام يحتوي على:
دوكسي سيكلين هيكليات ٤٦١.٦ مج( دوكسي سيكلين قاعدي ٤٠٠مج)
برومهكسين هيدروكلوريد ٤٣.٩مج
(برومهكسين ٤٠ مج)
الاستخدامات
_هكساسيكلين مضاد حيوي واسع الطيف والمدي ضد البكتيريا السالبة والبكتيريا الموجبه لصبغه الجرام
– هكساسيكلين لعلاج مشاكل الأمراض التنفسية المزمنه CRD
_ هكساسيكلين يستخدم لعلاج الرشح المذمن في التجوايف الأنفية ويستخدم لعلاج التهابات الاكياس الهوائية
– هكساسيكلين يقلل من لزوجه المخاط
_ هكساسيكلين يزيد من نشاط اهداب الجهاز التنفسي
– هكساسييكلين يستخدم لعلاج ألامراض المعويه التي تسببه اي كولي والباستوريلا
الجرعه
١ جرام هكساسيكلين علي ٢ لتر مياه شرب لمده ٣- ٥ ايام
انتاج شركه إيڤا فارما توزيع العفت ترايدنج
Hexacycline
Composition :
Each 1 gm contains:
– Doxycycline (as hyclate) 400 mg + Bromhexine (as hydrochloride) 40 mg
Properties :
Doxycycline: has broad spectrum activity inhibiting both aerobic and anaerobic gram-posi�tive and gram-negative bacteria, mycoplasmas, chlamydiae, rickettsias and some protozoa.
Bromhexine is a mucoregulator. By activating the secretion of the seromucous glands, It
breaks down the network of acid glycoprotein fibres found in mucoid sputum, which are
mainly responsible for the characteristic viscosity.
Mechanism of Action:
Doxycycline inhibits bacterial protein synthesis. Doxycycline binds to the 30S ribosomal
subunit, which prevents the tRNA from binding to the ribosome. This prevents the mRNA
from being translated into protein, which is essential for bacterial growth and reproduction.
Bromhexine acts by inhibiting neuraminidase, stabilizing lysosomes, increasing ciliary
activity, hydrating mucus, and exhibiting anti-inflammatory effects.
Strength points of Hexacycline:
Hexacycline Synergistic effect: Doxycycline is a broad-spectrum antibiotic that is effective
against a wide range of bacteria, including Mycoplasma gallisepticum, which is a common
cause of respiratory infections in poultry. Bromhexine is an expectorant that helps to loosen
mucus and clear congestion. When used together, doxycycline and bromhexine can be more
effective than either drug alone in treating respiratory
infections.
Hexacycline Improved absorption: Bromhexine can help to improve the absorption of doxy�cycline, which means that it is effective in the lower doses.
Hexacycline is effective against a wide range of Gram-positive and Gram-negative bacteria,
making it a versatile antibiotic for poultry.
Hexacycline has a long half-life, meaning it remains in the body for an extended period,
providing prolonged protection against bacterial infections.
Hexacycline Reduced Respiratory Distress: By assisting in clearing mucus and improving
airway function, bromhexine may contribute to reducing respiratory distress in affected
poultry
Dose of whole product:
Broilers chickens: 0.5 gm of the product / 1 liter drinking water
Produced by EVA PHARMA distributor by Aleffat trading
| Agency |
EVA Pharma |
|---|
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Oxytetracycline is a broad-spectrum antibiotic. It is mainly active against Gram-positive and Gram negative bacteria, aerobic and anaerobic, mycoplasma, Chlamydia and Rickettsiae It acts by reversibly to the ribosomal subunit 30S receptors to a blockage of the union between aminoacyl-tRNA to the site corresponding to the mRNA-ribosome complex messenger. Then inhibition of the protein synthesis and inhibits bacterial growth. Indications: Chicktetra is used for the treatment of: Broiler chickens: *Arthritis caused by Staphylococcus aureus. *Chronic Respiratory Disease (CRD) caused by Mycoplasma gallisepticum. *Infectious enteritis caused by E. coli. *Fowl cholera caused by Pasteurella multocida. *Fowl coryza caused by Haemophilus paragallinarum. *Gangrenous dermatitis caused by Clostridium spp. *Typhoid & paratyphoid caused by Salmonella spp. Pre – ruminating calves: *Bovine pneumonia caused by Mycoplasma bovis , Pasteurella haemolytica , P. multocida & Haemophilus somnus. *Scours , neonatal diarrhea caused by E. coli & Salmonella spp. Target Species Broiler Chickens ,pre-ruminating calves Dosage and administration:
by addition to drinking water From active ingredient : Broiler chickens: 20mg of oxytetracycline /kg body weight 3-5 days Pre – ruminating calves: 10-30 mg / kg bodyweight 1-2 times daily From whole product Broiler chickens: 0.5 gm of product / liter of drinking water 3-5 days Pre – ruminating calves: 2.5gm7.5gm of product /100 kg body weight 1-2 times daily Warning and precautions : Should be dissolved in water, before use. Prolonged or repeated use should be avoided Do not use in laying birds producing eggs intended for human consumption Contra indications hypersensitivity to oxytetracycline or any other substance from tetracyclines group. Side effects: gastro-intestinal disorder and less frequently, allergic and photosensitivity reactions. Interaction with other drugs: should not be administered with antacids, gels containing aluminium, preparations containing vitamins or minerals as insoluble complexes will be formed, which decreases the absorption of the antibiotic. Withdrawal period Meat and offal:7 days Eggs: do not use in laying birds producing eggs intended for human consumption Storage: Keep on cool &dry place not exceeding 30° C. Keep out of reach of children. Manufactured by Eva pharm distribution by "Aleffat trading "
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Composition: - Tylosin tartarate 110gm Equivalent to Tylosin 100 gm Properties : Tylosin is a macrolide antibiotic which acts by inhibiting bacterial protein synthesis through binding to 50S ribosomal subunits within cell wall . It has antibacterial spectrum that is essentially against gram +ve bacteria including (Actinomyces spp . Erysipelothrix rhusiopathiae), certain gram – ve. bacteria including Pasteurella spp and Fusobacterium necrophorum)and certain Spirochetes (as Treponema hyodysenteriae). Indications: Pre ruminant Calves: Treatment of pneumonia caused by Mycoplasma spp when the disease has been established in the herd. Broiler Chickens: Treatment of chronic respiratory diseases (CRD) caused by Mycoplasma gallisepticum and Mycoplasma synoviae when the disease has been established in the flock. Treatment and prevention of necrotic enteritis caused by Clostridium perfringens when the disease has been established in the flock Turkeys: Treatment of infectious sinusitis caused by Mycoplasma gallisepticum. when the disease has been established in the flock Target species: Broiler Chickens, pre ruminate Calves, Turkeys Dosage and administration: by addition to drinking water From active ingredient Pre ruminant Calves: 10 – 20 mg tylosin per kg BW twice daily for 7 - 14 days. Turkeys: 75 – 100 mg tylosin per kg BW per day for 3 – 5 days Broiler Chickens: For the treatment of chronic respiratory disease: 75 – 100 mg tylosin per kg BW per day for 3 – 5 days. From whole product Pre ruminant Calves: 0.54 gm-1.08gm of product per 50 kg BW twice daily for 7 - 14 days. Turkeys: 0.81 gm –1.082 gm /10 kg BW( 1 liter ) per day for 3 – 5 days Broiler Chickens: 0.81 gm –1.082 gm /10 kg BW( 1 liter ) day for 3 – 5 days Contra indications: It shouldn’t be used in layers producing eggs for human consumption Drug interactions Because tylosin is related to macrolides group, it interacts with Clindamycin (increase antagonism of effect) Side effects:Diarrhoea, epigastric pain Withdrawal period: Pre ruminant Calves (meat and offal): 12 days Turkeys (meat and offal): 2 days, Turkey (eggs): Zero days Broiler Chickens (meat and offal): 1 day, Chicken (eggs): Zero days Manufactured by Eva pharm distribution by "Aleffat trading "




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